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Alteration of the inner surface of venous catheters by antineoplastic drugs.

Authors
  • Tabone, E1
  • Latour, J F
  • Mignot, A
  • Ranchere, J Y
  • 1 Centre Léon Bérard, Lyon, France. , (France)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Oct 01, 1991
Volume
12
Issue
8
Pages
741–746
Identifiers
PMID: 1724733
Source
Medline
License
Unknown

Abstract

Septic complications and thrombosis are frequent causes of long-term venous catheter implantation failure and tend to occur more frequently in oncology than in patients using catheters for hyperalimentation only. The purpose of this in vitro study was to study extensively the inner surface behaviour and the possible changes in their mechanical properties of various silicone and polyurethane catheters after exposure to a flow of the most common antineoplastic drugs. Silicone catheters appeared to be the best choice for cytostatic drug infusions because of their chemical stability, but the addition of an opacifier imposes a protective inner and outer layer to improve their surface properties for biocompatibility.

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