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Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.

Authors
Type
Published Article
Journal
Lung Cancer
0169-5002
Publisher
Elsevier
Publication Date
Volume
60
Issue
2
Pages
277–284
Identifiers
PMID: 18061304
Source
Medline
License
Unknown

Abstract

The results of this study suggest that APE1/ref-1 is up-regulated in the tumor regions of NSCLC. Altered expression of antioxidant systems lead to enhanced production of superoxide production and lipid peroxidation, which can induce APE1/ref-1 in the tumor regions of NSCLS.

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