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Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.

Authors
  • Yoo, Dae Goon
  • Song, Yun Jeong
  • Cho, Eun Jung
  • Lee, Sang Ki
  • Park, Jin Bong
  • Yu, Jae Hyeon
  • Lim, Seung Pyung
  • Kim, Jin Man
  • Jeon, Byeong Hwa
Type
Published Article
Journal
Lung Cancer
Publisher
Elsevier
Publication Date
May 01, 2008
Volume
60
Issue
2
Pages
277–284
Identifiers
PMID: 18061304
Source
Medline
License
Unknown

Abstract

The results of this study suggest that APE1/ref-1 is up-regulated in the tumor regions of NSCLC. Altered expression of antioxidant systems lead to enhanced production of superoxide production and lipid peroxidation, which can induce APE1/ref-1 in the tumor regions of NSCLS.

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