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Alterated integrin expression in lichen planopilaris

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BioMed Central
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PMC
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  • Research
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  • Medicine

Abstract

1746-160X-3-11.fm ral ss BioMed CentHead & Face Medicine Open AcceResearch Alterated integrin expression in lichen planopilaris Roberto d'Ovidio1, Concetta Sgarra2, Anna Conserva3, Umberto Filippo Angelotti2, Roberta Erriquez2 and Caterina Foti*3 Address: 1Specialist in Dermatology-AIDA/Tricologia, Bari, Italy, 2Department of Internal Medicine, Immunology and Infectious Diseases, Unit of Internal Medicine, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy and 3Department of Internal Medicine, Immunology and Infectious Diseases, Unit of Dermatology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy Email: Roberto d'Ovidio - [email protected]; Concetta Sgarra - [email protected]; Anna Conserva - [email protected]; Umberto Filippo Angelotti - [email protected]; Roberta Erriquez - [email protected]; Caterina Foti* - [email protected] * Corresponding author Abstract Background: Lichen planopilaris (LPP) is an inflammatory disease characterized by a lymphomononuclear infiltrate surrounding the isthmus and infundibulum of the hair follicle of the scalp, that evolves into atrophic/scarring alopecia. In the active phase of the disease hairs are easily plucked with anagen-like hair-roots. In this study we focused on the expression of integrins and basement membrane components of the hair follicle in active LPP lesions. Methods: Scalp biopsies were taken in 10 patients with LPP and in 5 normal controls. Using monoclonal antibodies against α3β1 and α6β4 integrins we showed the expression of these integrins and of the basement membrane components of the hair follicle in active LPP lesions and in healthy scalp skin. Results: In the LPP involved areas, α3β1 was distributed in a pericellular pattern, the α6 subunit was present with a basolateral distribution while the β4 subunit showed discontinuous expression at the basal pole and occasionally, basolateral staining of the hair follicle. Conclusion: An altered dis

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