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Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice

Authors
  • elshikha, ahmed s.
  • abboud, georges
  • van der meijden-erkelens, lonneke
  • yuanqing, lu
  • chen, mong-jen
  • yuan, ye
  • ponjee, godelieva
  • zeumer, leilani
  • satoh, minoru
  • morel, laurence
  • song, sihong
Publication Date
Aug 29, 2019
Identifiers
DOI: 10.3390/jcm8091341
OAI: oai:mdpi.com:/2077-0383/8/9/1341/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

production in B cells, as well as CD4+ T cells in untreated mice. Conversely, the frequency of regulatory CD4+CD25+ and CD4+CD25-IL-10+ cells was significantly higher in hAAT-Tg than in B6 mice. This confirmed the anti-inflammatory effect of hAAT that was observed even at steady state. One week after a pristane injection, the frequency of peritoneal Ly6Chi inflammatory monocytes and neutrophils in hAAT-Tg mice was significantly lower than that in B6 mice. Importantly, pristane-induced DAH was completely prevented in hAAT-Tg mice and this was associated with a modulation of anti- to pro-inflammatory myeloid cell ratio/balance. We also showed that treatment with hAAT decreased the severity of DAH in B6 mice. These results showed for the first time that hAAT has a therapeutic potential for the treatment of DAH.

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