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alpha-Tocopherol (vitamin E) content of lung, liver, and blood in the newborn rat and human infant: influence of hyperoxia.

Authors
Type
Published Article
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
98
Issue
5
Pages
806–811
Identifiers
PMID: 7229766
Source
Medline
License
Unknown

Abstract

Increases in liver and lung alpha-tocopherol (vitamin E) content occur concurrent with birth and the onset of suckling in the newborn rat and are prevented by denying pups access to dams. Liver alpha-tocopherol concentration peaks at 24 hours of age and then declines, whereas the lung concentration of alpha-tocopherol continues to increase in the early neonatal period. These tissue changes are not reflected by changes in the blood alpha-tocopherol concentration. Significant increases in lung alpha-tocopherol result from administering alpha-tocopherol (100 mg/kg body weight, sc) on days 0, 2, and 4 of age. Studies of lung alpha-tocopherol concentrations in infants with varying histories of alpha-tocopherol exposure confirm the findings in the rat, and suggest that increases in lung alpha-tocopherol concentration result from administration of alpha-tocopherol in the immediate newborn period. Studies of alpha-tocopherol values in alpha-tocopherol-treated and control newborn rats reveal no significant changes in lung tocopherol concentration resulting from exposure to hyperoxia.

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