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Alpha-fetoprotein producing undifferentiated carcinoma of the bladder.

Authors
  • Yamada, K
  • Fujioka, Y
  • Ebihara, Y
  • Kiriyama, I
  • Suzuki, H
  • Akimoto, M
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Sep 01, 1994
Volume
152
Issue
3
Pages
958–960
Identifiers
PMID: 7519684
Source
Medline
License
Unknown

Abstract

We report on a rare primary undifferentiated carcinoma of the bladder producing alpha-fetoprotein in a woman. Definitive features included an aggressive, invasive and rapidly growing tumor with a hepatoid carcinomatous lesion on histological examination. Histopathological findings suggested that the multipotent transitional cell induces production of alpha-fetoprotein. The association of an aggressive tumor with the ability to produce this antigen suggests a possible benefit in measuring serum alpha-fetoprotein levels and examining histological sections for its expression in primary undifferentiated carcinoma of the bladder. Further study may indicate radical cystectomy when the resected specimen produces alpha-fetoprotein, particularly if tumors appear to be aggressive and highly vascularized as in our case.

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