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Alpha-fetoprotein-mediated targeting--a new strategy to overcome multidrug resistance of tumour cells in vitro.

Authors
  • Posypanova, G A
  • Shmyrev, I I
  • Rodina, A V
  • Muizhnek, E L
  • Severin, E S
  • Luzhkov, Y M
  • Severin, S E
Type
Published Article
Journal
Cell biology international
Publication Date
Dec 01, 1997
Volume
21
Issue
12
Pages
793–799
Identifiers
PMID: 9812343
Source
Medline
License
Unknown

Abstract

The possibility of overcoming the multidrug resistance of human malignant cells by using doxorubicin conjugated to alpha-fetoprotein (AFP) was studied. It was shown that this type of antitumour drugs, penetrating the cell by receptor-mediated endocytosis with AFP as a vehicle, raises the sensitivity of the tumour cells that are resistant due to the expression of the multidrug resistance gene mdr1. The sensitivity of antibiotic-resistant cell lines SKVLB (a human ovarian carcinoma) and MCF-7 AdrR (a human breast carcinoma) increased by 10- and 4-fold, respectively, when AFP-conjugated doxorubicin was used. The rationale of using human AFP-antitumour drug conjugates for the development of new chemotherapeutic approaches to cancer treatment is discussed.

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