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Alpha(2A)-adrenoceptors regulate sympathetic transmitter release in mice kidneys.

Authors
  • Vonend, O
  • Habbel, S
  • Stegbauer, J
  • Roth, J
  • Hein, L
  • Rump, L C
Type
Published Article
Journal
British journal of pharmacology
Publication Date
Jan 01, 2007
Volume
150
Issue
1
Pages
121–127
Identifiers
PMID: 17115069
Source
Medline
License
Unknown

Abstract

alpha(2A)-Adrenoceptor-activation inhibits NA and ATP release from renal sympathetic nerves. Pressor responses to RNS at higher stimulation frequencies (>2 Hz) are mediated by NA. At lower frequencies neuronally released ATP seems to be the predominant transmitter mediating renovascular resistance.

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