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Alpha-1-antitrypsin deficiency asthma and allergy.

Authors
  • Palma-Carlos, A G
  • Palma-Carlos, M L
Type
Published Article
Journal
European annals of allergy and clinical immunology
Publication Date
Apr 01, 2007
Volume
39
Issue
4
Pages
127–132
Identifiers
PMID: 17523387
Source
Medline
License
Unknown

Abstract

The biochemistry, genetics and pathology of alpha-1-anti-trypsin deficiency are reviewed. The geographical distribution in Europe of more current phenotypes M, SZ is discussed. Two cases of alpha-1- anti-trypsin are presented one homozygotic ZZ non-smoker without any respiratory pathology and one heterozygotic SZ heavy smoker with a severe chronic obstructive pulmonary disease and reversibility to Beta-2-mimetics suggesting asthma. The relationship between alpha-1-antitrypsin and asthma is discussed and general measures of treatment or prevention suggested.

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