Affordable Access

An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.

Authors
  • Alkassab, F
  • Gourh, P
  • Tan, F K
  • McNearney, T
  • Fischbach, M
  • Ahn, C
  • Arnett, F C
  • Mayes, M D
Type
Published Article
Journal
Rheumatology (Oxford, England)
Publication Date
Aug 01, 2007
Volume
46
Issue
8
Pages
1248–1251
Identifiers
PMID: 17522098
Source
Medline
License
Unknown

Abstract

The data demonstrate a genetic association between AIF1 and the ACA-positive subset of SSc. This polymorphism is a non-synonymous substitution and therefore likely to represent an important functional change in AIF1. Since vascular pathology is a prominent feature in ACA-positive SSc patients, the observed association with a vasculotrophic inflammatory gene is biologically plausible and warrants further research.

Report this publication

Statistics

Seen <100 times