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Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers

Authors
  • Wang, Xiaoming
  • Wang, Yue
  • Fang, Ci
  • Gong, Qianmei
  • Huang, Jinhu
  • Zhang, Yujuan
  • Wang, Liping
Type
Published Article
Journal
Poultry Science
Publisher
Elsevier
Publication Date
May 05, 2022
Volume
101
Issue
7
Identifiers
DOI: 10.1016/j.psj.2022.101947
PMID: 35688033
PMCID: PMC9189214
Source
PubMed Central
Keywords
Disciplines
  • ANIMAL WELL-BEING AND BEHAVIOR
License
Unknown

Abstract

Allicin, one of the main bioactive compounds in garlic, is an excellent feed additive. It is unknown whether allicin affects the expression of P-gp and BCRP, 2 important ABC efflux transporters related to the pharmacokinetics of antimicrobials in chickens. In this study, by bidirectional transport test and broiler jejunum in situ perfusion, we found that allicin inhibited the efflux transport of P-gp and BCRP for their substrates sulfadiazine and florfenicol, 2 commonly used antimicrobials in broilers. Furthermore, we observed that allicin decreased the mRNA expression of chicken jejunum P-gp and BCRP. Pretreatment with allicin changed the pharmacokinetic behavior of orally administered sulfadiazine, by increasing AUC (41.85 vs. 31.24, P < 0.01) and Cmax values (9.82 vs. 8.40, P < 0.05) and decreasing CLZ (0.45 vs. 0.62, P < 0.01). Similarly, pretreatment with allicin also altered pharmacokinetics of orally administered florfenicol, by increasing AUC (18.38 vs. 13.52, P < 0.01) and decreasing CLZ. The results indicate that allicin could inhibit jejunum P-gp and BCRP expression and efflux function, thereby increasing the plasma concentrations of their substrates in broilers.

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