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[Allergic respiratory diseases related to mould in the home].

Authors
  • Schaller, A1
  • Delmas, C2
  • De Blay, F3
  • 1 Pôle de pathologie thoracique, service de pneumologie, Nouvel hôpital civil, 1, place de l'hôpital, 67094 Strasbourg cedex, France. Electronic address: [email protected] , (France)
  • 2 Pôle de pathologie thoracique, service de pneumologie, Nouvel hôpital civil, 1, place de l'hôpital, 67094 Strasbourg cedex, France. , (France)
  • 3 Pôle de pathologie thoracique, service de pneumologie, Nouvel hôpital civil, 1, place de l'hôpital, 67094 Strasbourg cedex, France; EA 3072, Fédération de médecine translationnelle, FHU OMICARE université de Strasbourg, 67000 Strasbourg, France. , (France)
Type
Published Article
Journal
Revue des maladies respiratoires
Publication Date
Sep 01, 2019
Volume
36
Issue
7
Pages
889–901
Identifiers
DOI: 10.1016/j.rmr.2018.10.619
PMID: 31303366
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

Exposure to mould is a potential risk factor for asthma in both adults and children. In adult, the relation between exposure, sensitization and symptoms has been demonstrated in severe asthmatics sensitized to Alternaria. For children, exposure to mould in childhood is a risk factor for asthma in both atopic and non-atopic individuals. Exposure or sensitization to moulds are a risk factor for severe asthma and/or exacerbations in children. There appears to be a causal relationship between exposure and asthma. This link seems less significant in adults. However, in adults mould sensitive asthma seems to determine a phenotype of severe asthma associated with more marked obstructive lung disease. Moulds can stimulate either innate or the acquired immunity. They are responsible for a marked Th2 inflammation leading to more severe asthma. Besides the immunological mechanisms, toxic mechanisms can also intervene. It is therefore not correct to reduce the effect of moulds, particularly in respiratory symptoms, to only allergic mechanisms. Copyright © 2019 SPLF. Published by Elsevier Masson SAS. All rights reserved.

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