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Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays.

Authors
  • Scantamburlo, Giada1
  • Tziolia, Konstantina2
  • Zopf, Michaela1
  • Bernardinelli, Emanuele3
  • Soyal, Selma M3
  • Civello, Davide Antonio3
  • Vanoni, Simone1
  • Dossena, Silvia3
  • Patsch, Wolfgang3
  • Patrinos, George P2, 4
  • Paulmichl, Markus5
  • Nofziger, Charity1
  • 1 PharmGenetix Gmbh, Niederalm-Anif, Niederalm-Anif, Austria. , (Austria)
  • 2 University of Patras School of Health Sciences, Department of Pharmacy, University Campus, Patras, Greece. , (Greece)
  • 3 Institute of Pharmacology and Toxicology, Paracelsus Medical University, Center for Pharmacogenetics and Pharmacogenomics, Salzburg, Austria. , (Austria)
  • 4 United Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, United Arab Emirates. , (United Arab Emirates)
  • 5 Center for Health & Bioresources, Austrian Institute of Technology (AIT), Vienna, Austria. , (Austria)
Type
Published Article
Journal
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Publication Date
Jan 01, 2017
Volume
43
Issue
6
Pages
2297–2309
Identifiers
DOI: 10.1159/000484380
PMID: 29073588
Source
Medline
Keywords
License
Unknown

Abstract

To evidence allele drop out and increase the accuracy of genotyping, intra-patient validation of the same genetic variation with at least two separate methods should be considered.

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