ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.
- Published Article
Science (New York, N.Y.)
- Publication Date
Jul 24, 1964
The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/14172601