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ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
145
Issue
3630
Pages
397–399
Identifiers
PMID: 14172601
Source
Medline
Keywords
  • Alkylating Agents
  • Alkylation
  • Antineoplastic Agents
  • Chemistry
  • Experimental Lab Study
  • Peptides
  • Polynucleotides
  • Protein Metabolism
  • Spectrum Analysis

Abstract

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.

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