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ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.

Authors
  • LUDLUM, D B
  • WARNER, R C
  • WAHBA, A J
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jul 24, 1964
Volume
145
Issue
3630
Pages
397–399
Identifiers
PMID: 14172601
Source
Medline
Keywords
License
Unknown

Abstract

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.

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