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Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity.

Authors
  • You, Young-Jae
  • Kim, Yong
  • Nam, Nguyen-Hai
  • Bang, Seong-Cheol
  • Ahn, Byung-Zun
Type
Published Article
Journal
European Journal of Medicinal Chemistry
Publisher
Elsevier
Publication Date
Feb 01, 2004
Volume
39
Issue
2
Pages
189–193
Identifiers
PMID: 14987827
Source
Medline
License
Unknown

Abstract

Esters of 4'-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT.

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