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Alkali and Alkaline Earth Metal Complexes as Versatile Catalysts for Ring‐Opening Polymerization of Cyclic Esters

  • Bhattacharjee, Jayeeta
  • Sarkar, Alok
  • Panda, Tarun K.
Publication Date
Jul 01, 2021
Research Archive of Indian Institute of Technology Hyderabad


Biodegradable polyesters such as poly(ϵ-caprolactone) (PCL) and poly(lactic acid) (PLA) have been considered for use in several areas, such as drug delivery devices, sutures, tissue engineering, and GBR membranes, due to its bio-renewability, biodegradability, and biocompatibility. Several synthetic techniques for the preparation of polyesters have been reported in the literature, amongst which the ring-opening polymerization (ROP) of cyclic esters is the most efficient. A convenient approach to access iso-selective PLAs is polymerization of racemic lactide (rac-LA), which shows excellent stereoregularity without the need for costly chiral auxiliaries or ligands. In this personal account, we review a series of methods that have been practiced to the synthesis of biodegradable polyesters from various cyclic monomers using alkali and alkaline earth metal complexes as efficient catalysts.

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