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Alisma orientale: Ethnopharmacology, Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine.

Authors
  • Shu, Zhiheng1, 2
  • Pu, Jiang3
  • Chen, Ling1
  • Zhang, Yuanbin2
  • Rahman, Khalid4
  • Qin, Luping1
  • Zheng, Chengjian1
  • 1 * Department of Pharmacognosy, School of Pharmacy Second Military Medical University, Shanghai 200433, P.R. China. , (China)
  • 2 † School of Pharmacy, Ningxia Medical University, Yinchuan 750004, P.R. China. , (China)
  • 3 ‡ Administrative Office, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China. , (China)
  • 4 § Faculty of Science, School of Biomolecular Sciences, Liverpool, John Moores University, Byrom Street, Liverpool L3 3AF, England, UK.
Type
Published Article
Journal
The American journal of Chinese medicine
Publication Date
Jan 01, 2016
Volume
44
Issue
2
Pages
227–251
Identifiers
DOI: 10.1142/S0192415X16500142
PMID: 27080939
Source
Medline
Keywords
License
Unknown

Abstract

Alisma orientale (Sam.) Juzep. (Alismataceae) is a traditional and famous Chinese medicinal herb. Its rhizomes, which possess versatile bioactivities, are commonly used to treat oliguria, edema, gonorrhea with turbid urine, leukorrhea, diarrhea and dizziness. Approximately 120 compounds have been isolated from A. orientale. Terpenoids have been identified as A. orientale's characteristic constituents, which include protostane triterpenoids and guaiane sesquiterpenoids. The traditional medical uses of A. orientale in TCM have been evaluated in modern pharmacological studies, which have shown that A. orientale and its active constituents exhibit a wide range of bioactivities, such as diuretic, anti-urolithiatic, antinephritic, anti-atherosclerotic, immunomodulatory, and hepatoprotective activities. The medicinal potential of A. orientale makes it an ideal candidate for new drug development. Further studies are still required to identify its bioactive constituents, and elucidate the structure-activity relationship and detailed mechanisms of action. Additionally, the use of the other medicinal parts of A. orientale may reduce resource waste and afford novel secondary metabolites.

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