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Alfentanil requirement in Crohn's disease. Increased alfentanil dose requirement in patients with Crohn's disease.

Authors
  • Gesink-van der Veer, B J
  • Burm, A G
  • Hennis, P J
  • Bovill, J G
Type
Published Article
Journal
Anaesthesia
Publication Date
Mar 01, 1989
Volume
44
Issue
3
Pages
209–211
Identifiers
PMID: 2495743
Source
Medline
License
Unknown

Abstract

The dose requirement of alfentanil as a supplement to nitrous oxide anaesthesia was studied in 13 patients with Crohn's disease and seven control patients all of whom underwent laparotomy. Alfentanil was administered as a variable rate infusion with supplemental bolus injections titrated to the patient's needs. The alfentanil requirement was independent of the duration of surgery and was significantly higher in patients with Crohn's disease than in control patients. The results indicate that Crohn's disease alters the dose requirement of alfentanil.

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