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Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation.

Authors
  • Liu, Selina L
  • Schmuck, Saskia
  • Chorazcyzewski, Jozef Z
  • Gros, Robert
  • Feldman, Ross D
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Nov 11, 2003
Volume
108
Issue
19
Pages
2400–2406
Identifiers
PMID: 14557368
Source
Medline
License
Unknown

Abstract

Overall, these data support a novel effect of aldosterone on vascular endothelial and smooth muscle cell function. These rapid effects of aldosterone might be important in both the short- and long-term regulation of peripheral vascular resistance. Furthermore, in the setting of endothelial dysfunction, alterations in aldosterone's short-term vascular responses might contribute to its pathophysiological effects in cardiovascular disease.

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