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Aldo-keto reductase family 1 member B10 is associated with hepatitis B virus-related hepatocellular carcinoma risk.

Authors
  • Mori, Masashi1, 2, 3
  • Genda, Takuya1
  • Ichida, Takafumi4
  • Murata, Ayato1
  • Kamei, Masato1
  • Tsuzura, Hironori1
  • Sato, Shunsuke1
  • Narita, Yutaka1
  • Kanemitsu, Yoshio1
  • Ishikawa, Sachiko1
  • Kikuchi, Tetsu1
  • Shimada, Yuji1
  • Hirano, Katsuharu4
  • Iijima, Katsuyori1
  • Sugimoto, Ken2
  • Wada, Ryo5
  • Nagahara, Akihito1
  • Watanabe, Sumio6
  • 1 Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
  • 2 First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
  • 3 Department of Internal Medicine, Fujinomiya City General Hospital, Shizuoka, Japan.
  • 4 Department of Hepatology, East Shonan General Hospital, Kanagawa, Japan.
  • 5 Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
  • 6 Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Type
Published Article
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
Publication Date
March 2017
Volume
47
Issue
3
Identifiers
DOI: 10.1111/hepr.12725
PMID: 27084455
Source
Medline
Keywords
License
Unknown

Abstract

Chronic HBV-infected patients with high hepatic AKR1B10 expression had an increased risk of HCC development. This suggests that AKR1B10 upregulation might play a role in the early stages of HBV-related hepatocarcinogenesis.

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