Affordable Access

ALDH1A1 (Aldehyde Dehydrogenase 1 family member A1)

Authors
  • Tunçer, Sinem
  • Çamlica, Rümeysa
  • Yilmaz, Idris
Publication Date
Jan 28, 2020
Source
I-Revues
Keywords
Language
English
License
Unknown
External links

Abstract

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the ALDH gene superfamily. Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) through NAD(P)+-dependent oxidation to their corresponding carboxylic acids or CoA esters. Different biological functions have been attributed to the different ALDH family members. The cytosolic enzyme ALDH1A1 is involved in the catalysis of retinol (vitamin A) metabolite retinaldehyde to retinoic acid (RA). RA acts as a ligand for the nuclear receptors retinoic receptor (RAR) and the retinoid X receptor (RXR) and therefore regulates the transcriptional activity of genes involved in multiple important processes including proliferation, differentiation, and apoptosis.

Report this publication

Statistics

Seen <100 times