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Alcoholic liver disease: Current insights into cellular mechanisms

Authors
  • Petagine, Lucy
  • Zariwala, Mohammed Gulrez
  • Patel, Vinood B
Type
Published Article
Journal
World Journal of Biological Chemistry
Publisher
Baishideng Publishing Group Co (World Journal of Chemistry)
Publication Date
Sep 27, 2021
Volume
12
Issue
5
Pages
87–103
Identifiers
DOI: 10.4331/wjbc.v12.i5.87
PMCID: PMC8473419
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Alcoholic liver disease (ALD) due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality. Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of ALD is widely recognized, the precise triggers for disease progression are still to be fully elucidated. Oxidative stress, mitochondrial dysfunction, gut dysbiosis and altered immune system response plays an important role in disease pathogenesis, triggering the activation of inflammatory pathways and apoptosis. Despite many recent clinical studies treatment options for ALD are limited, especially at the alcoholic hepatitis stage. We have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients.

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