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Albumin-based drug delivery: harnessing nature to cure disease

Authors
  • Larsen, Maja Thim1
  • Kuhlmann, Matthias1
  • Hvam, Michael Lykke1
  • Howard, Kenneth A.1
  • 1 Department of Molecular Biology and Genetics, University of Aarhus, Interdisciplinary Nanoscience Center (iNANO), Aarhus, Denmark , Aarhus (Denmark)
Type
Published Article
Journal
Molecular and Cellular Therapies
Publisher
"ClinTransMed, AB"
Publication Date
Feb 27, 2016
Volume
4
Issue
1
Identifiers
DOI: 10.1186/s40591-016-0048-8
Source
Springer Nature
Keywords
License
Green

Abstract

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform.

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