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Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications

Authors
  • Srivastava, Abhishek1
  • Prajapati, Anjali1
  • 1 GLA University, India , (India)
Type
Published Article
Journal
Asian Biomedicine
Publisher
Sciendo
Publication Date
Dec 31, 2020
Volume
14
Issue
6
Pages
217–242
Identifiers
DOI: 10.1515/abm-2020-0032
Source
De Gruyter
Keywords
License
Green

Abstract

The inherent properties of albumin facilitate its effective use as a raw material to prepare a nanosized drug delivery vehicles. Because of the enhanced surface area, biocompatibility, and extended half-life of albumin nanoparticles, a number of drugs have been incorporated in albumin matrices in recent years. Furthermore, its ability to be conjugated to various receptor ligands makes albumin an ideal candidate for the increased delivery of drugs to specific sites. The present review provides an in-depth discussion of production strategies for the preparation of albumin and conjugated albumin nanoparticles and for the targeting of these formulations to specific organs and cancer cells. This review also provides insights into drug loading, release patterns, and cytotoxicity of various drug-loaded albumin nanoparticles.

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