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Alanyl-PNA homoduplex: A-T pairing with the N7-regioisomer of adenine.

Authors
  • Diederichsen, U
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
165–168
Identifiers
PMID: 9871647
Source
Medline
License
Unknown

Abstract

The N7-regioisomer of adeninyl alanine can be used as a building block for the synthesis of alanyl-PNA. By changing the nucleobase connectivity from N9 to N7, pairing with the Hoogsteen side is no longer possible and the order of donor/acceptor positions at the Watson-Crick side is reversed. This influences the pairing selectivity but not the stability of alanyl-PNA self-pairing complexes, as shown by UV and CD spectroscopy.

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