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Aiming for a shorter time to diagnosis: pediatric eosinophilic esophagitis in British Columbia

Authors
  • Jia, Jocelyn1, 2
  • Chan, Edmond S.2, 3
  • Avinashi, Vishal2, 3
  • Hsu, Elaine2, 3
  • Ko, Hin Hin3, 4
  • Soller, Lianne2, 3
  • 1 University of Toronto, Toronto, ON, Canada , Toronto (Canada)
  • 2 BC Children’s Hospital Research Institute, Vancouver, BC, Canada , Vancouver (Canada)
  • 3 University of British Columbia, Vancouver, BC, Canada , Vancouver (Canada)
  • 4 St. Paul’s Hospital, Vancouver, BC, Canada , Vancouver (Canada)
Type
Published Article
Journal
Allergy, Asthma & Clinical Immunology
Publisher
BioMed Central
Publication Date
Oct 14, 2020
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s13223-020-00486-2
Source
Springer Nature
Keywords
License
Green

Abstract

Longer time to diagnosis for patients with eosinophilic esophagitis can lead to adverse patient outcomes, but the length of diagnostic delay has not been quantified for patients with eosinophilic esophagitis in Canada. Our study defines the time to diagnosis (TTD) for pediatric patients with eosinophilic esophagitis in British Columbia and identifies factors that predict increased time to diagnosis. The median TTD was 21 months (1.75 years; IQR = 7, 45) with a median age at EoE diagnosis of 105 months (8.75 years; IQR = 44, 156). Caucasians experienced significantly longer TTD compared to other ethnicities (24 months (IQR = 7, 52) and 12 months (IQR = 4.5, 23) respectively, p = 0.008). Caucasian ethnicity (p = 0.037) and older age at the time of diagnosis (p = 0.006) predicted increased TTD. Our model explained 7.9% (Adjusted R2 = 0.079) of the total variance for our cohort.

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