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AIDS wasting syndrome as an enterometabolic disorder: the gut hypothesis.

Authors
  • Kaminski, M Jr
  • Weil, S
  • Bland, J
  • Jan, P
Type
Published Article
Journal
Alternative medicine review : a journal of clinical therapeutic
Publication Date
Feb 01, 1998
Volume
3
Issue
1
Pages
40–53
Identifiers
PMID: 9600025
Source
Medline
License
Unknown

Abstract

There is an interesting relationship between the HIV virus, the health of the gastrointestinal tract, and AIDS wasting syndrome, involving Tumor Necrosis Factor alpha (TNF alpha), specific and non-specific immunity in the gut, gut permeability, and oxidative stress. It is hypothesized that the progression of HIV to full-blown AIDS may be impacted by maintaining a healthy gut. A therapeutic protocol which decreases oxidative stress, inhibits TNF alpha, enhances phase I and II liver detoxification, and improves specific and non-specific immunity in the gut should be part of a therapeutic protocol for HIV-infected individuals. Through a better understanding of the pathophysiology of HIV advancing to AIDS, the practitioner can develop a treatment strategy of nutritional and lifestyle changes which could theoretically prevent an HIV infection from advancing to full-blown AIDS.

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