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Development and regulation of RORγt+ innate lymphoid cells

Authors
  • Cording, Sascha
  • Medvedovic, Jasna
  • Cherrier, Marie
  • Eberl, Gérard1, 2, 3, 4
  • 1 Institut Pasteur
  • 2 Development of Lymphoid Tissues Unit
  • 3 INSERM U 1151
  • 4 Institut Necker Enfants Malades – Faculté de Médecine Paris Descartes
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2014
Accepted Date
Mar 18, 2014
Identifiers
DOI: 10.1038/nature13047
Source
Elsevier
Keywords
License
Unknown

Abstract

RORγt+ innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.

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