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AhR activation defends gut barrier integrity against damage occurring in obesity

Authors
  • Postal, Bárbara G.1, 2
  • Ghezzal, Sara1
  • Aguanno, Doriane1, 2, 3
  • André, Sébastien4
  • Garbin, Kevin5
  • Genser, Laurent4
  • Brot-Laroche, Edith1
  • Poitou, Christine4, 6
  • Soula, Hédi4
  • Leturque, Armelle1, 4
  • Clément, Karine4, 6
  • Carrière, Véronique1, 2
  • 1 Cordeliers Research Center, Sorbonne University, Paris Dauphine University 05, INSERM, CNRS, F-75006, Paris, France
  • 2 Saint-Antoine Research Center, Sorbonne University, INSERM, F-75012, Paris, France
  • 3 EPHE, PSL Research University, F-75006, Paris, France
  • 4 Sorbonne University, INSERM, NutriOmics Research Unit Paris, F-75013, France
  • 5 CHIC Platform of Cordeliers Research Center, Sorbonne University, UPD Univ Paris 05, INSERM, F-75006, Paris, France
  • 6 Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, CRNH Ile de France, F-75013, Paris, France
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Apr 28, 2020
Volume
39
Identifiers
DOI: 10.1016/j.molmet.2020.101007
PMID: 32360426
PMCID: PMC7267728
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Intestinal inflammation in obese subjects correlates with low AhR activity. • AhR activation protects intestinal epithelium from damages. • AhR activation prevents cytokine induction in response to damages. • Protective role of AhR activation targets junctional complexes. • Protein kinases-dependent signaling pathways are involved in AhR action.

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