Genetic modification (GM) of crops is a technique that involves the transfer of a genetic material from one organism, including plants, animals, or microorganisms, into a different organism, modifying the plants’ characteristics. The technology provides different approaches towards agricultural improvements (environmental, nutritional, yield increases, etc.), which maintained the global food security (quality and safety). However, the opponents have kept on fighting against the technology in a way that merely addresses the potential risks with disregard to the benefits. Some of the arguments which are commonly addressed against the agricultural biotechnology are the negative impacts of overproduction, unnatural biological diversity and the domination of multinational agribusiness corporations. Therefore, the present review reveals an insight towards the negative and positive effects of GM crops on human health and the environment including ethical concerns. The write up will also be an overview that addresses the importance of GM crops and the moral imperative including religious perspectives, thus, providing the public awareness towards accepting the biotechnology.