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Aging-related tumor associated fibroblasts changes could worsen the prognosis of GBM patients

Authors
  • Song, Hongwang1
  • Fu, Xiaojun2
  • Wu, Chenxing2
  • Li, Shouwei2
  • 1 Shengjing Hospital of China Medical University, Shenyang, China , Shenyang (China)
  • 2 Capital Medical University, Xiangshanyikesong 50#, HaiDian District, Beijing, 100093, China , Beijing (China)
Type
Published Article
Journal
Cancer Cell International
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 08, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12935-020-01571-7
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain, with highly heterogeneity among different patients. Age could function as an incidence and prognosis risk factor for many tumors.MethodA series of bioinformatic experiments were conducted to evaluate the differences of incidence, differential expressed genes, enriched pathways with the data from Surveillance, Epidemiology, and End Results (SEER) program, the cancer genome atlas (TCGA) and Chinese glioma genome atlas (CGGA) project.ResultsWe discovered in our present study that distinct difference of incidence and prognosis of different aged GBM patients. By a series of bioinformatic method, we found that the tumor associated fibroblasts (TAFs) was the most crucial tumor microenvironment (TME) component that led to this phenomenon. Epithelial-mesenchymal transition (EMT) could be the mechanism by which TAFs regulate the progression of GBM.ConclusionWe have proposed a close correlation between age and GBM incidence and prognosis, and propose the underlying mechanism behind this correlation by mining different databases, which laid the foundation for future research.

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