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Aging, VO 2 max, entropy, and COVID-19

Authors
  • Spedding, Michael
  • Marvaud, Robin
  • Marck, Adrien
  • Delarochelambert, Quentin
  • Toussaint, Jean Francois
Type
Published Article
Journal
Indian Journal of Pharmacology
Publisher
Wolters Kluwer - Medknow
Publication Date
Mar 18, 2022
Volume
54
Issue
1
Pages
58–62
Identifiers
DOI: 10.4103/ijp.ijp_442_21
PMID: 35343209
PMCID: PMC9012415
Source
PubMed Central
Keywords
Disciplines
  • Review Article
License
Unknown

Abstract

The decline in human performance with age at 5000 m, an athletic event requiring high VO2 max, is remarkably precise, and unavoidable, and related to entropy, even at an individual level. Women and men show an identical age-related decline, up to ~100 years old. The precision of the decline shows the limitations for therapy of aging. Mortality incidence for COVID-19 shows a similar relationship. We propose that initial VO2 max has a critical role in COVID sensitivity because of the direct relationship of disease severity with oxygen use, and the parallel decline in aging.

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