Affordable Access

Publisher Website

Aging microglia.

Authors
  • Antignano, Ignazio1
  • Liu, Yingxiao1
  • Offermann, Nina1
  • Capasso, Melania2
  • 1 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. , (Germany)
  • 2 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. [email protected]. , (Germany)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Apr 21, 2023
Volume
80
Issue
5
Pages
126–126
Identifiers
DOI: 10.1007/s00018-023-04775-y
PMID: 37081238
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects. © 2023. The Author(s).

Report this publication

Statistics

Seen <100 times