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Aging, immunity and cancer.

Authors
Type
Published Article
Journal
Current Opinion in Immunology
0952-7915
Publisher
Elsevier
Publication Date
Volume
16
Issue
2
Pages
151–156
Identifiers
PMID: 15023406
Source
Medline

Abstract

Immunosenescence, the progressive decline in immune function that develops with age, results from cumulative alterations in critical B- and T-cell subpopulations. Decreases in circulating memory B cells and in germinal center formation are evident in the elderly, possibly due to diminished follicular dendritic-cell function. T-cell dysfunction is associated with reduced thymic generation of naïve T cells, virus-induced expansion of terminal effectors and increased levels of memory cells producing type I and II cytokines. The diversity of the T-cell receptor repertoire is diminished by the first two changes, and elevated type I cytokines might contribute to the pro-inflammatory cytokine milieu present in the elderly.

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