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Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation.

Authors
  • Schatz, D
  • Ellis, T
  • Ottendorfer, E
  • Jodoin, E
  • Barrett, D
  • Atkinson, M
Type
Published Article
Journal
Clinical and Diagnostic Laboratory Immunology
Publisher
American Society for Microbiology
Publication Date
Nov 01, 1998
Volume
5
Issue
6
Pages
894–896
Identifiers
PMID: 9801353
Source
Medline
License
Unknown

Abstract

The period of efficacious immune reactivity afforded by tetanus immunization and the need for continuing some forms of tetanus vaccination programs have been the subjects of recent debates. Our studies demonstrate that the level of antitetanus immunity based on immunological memory (i.e., cellular immune responsiveness) varies dramatically as a function of age, with older individuals constituting a population which is increasingly susceptible to tetanus infection.

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