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Aging attenuates the pituitary response to gonadotropin-releasing hormone.

Authors
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
1945-7197
Publisher
The Endocrine Society
Publication Date
Volume
94
Issue
9
Pages
3259–3264
Identifiers
DOI: 10.1210/jc.2009-0526
PMID: 19549740
Source
Medline
License
Unknown

Abstract

In studies that isolated the pituitary from endogenous GnRH stimulation, aging attenuated the LH and FSH responses to exogenous GnRH in PMW. These studies indicate that the pituitary plays a role in the decline in gonadotropin levels with aging, further supporting the potential contribution of age-associated changes in both hypothalamic and pituitary function to reproductive senescence.

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