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Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease.

Authors
  • Farid, Marjan1
  • Agrawal, Anshu2
  • Fremgen, Daniel1
  • Tao, Jeremiah1
  • Chuyi, He1
  • Nesburn, Anthony B1
  • BenMohamed, Lbachir1, 3, 4
  • 1 a Laboratory of Cellular and Molecular Immunology , Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine , California , USA .
  • 2 b Division of Basic and Clinical Immunology, Department of Medicine , University of California Irvine, School of Medicine , Irvine , California , USA .
  • 3 c Department of Molecular Biology , University of California Irvine, School of Medicine , Irvine , California , USA .
  • 4 d Biochemistry and Institute for Immunology, University of California Irvine, School of Medicine , Irvine , California , USA.
Type
Published Article
Journal
Ocular Immunology and Inflammation
Publisher
Informa UK (Taylor & Francis)
Publication Date
June 2016
Volume
24
Issue
3
Pages
327–347
Identifiers
DOI: 10.3109/09273948.2014.986581
PMID: 25535823
Source
Medline
Keywords
License
Unknown

Abstract

Dry eye disease (DED) is a prevalent public health concern that affects up to 30% of adults and is particularly chronic and severe in the elderly. Two interconnected mechanisms cause DED: (1) an age-related dysfunction of lacrimal and meibomian glands, which leads to decreased tear production and/or an increase in tear evaporation; and (2) an age-related uncontrolled inflammation of the surface of the eye triggered by yet-to-be-determined internal immunopathological mechanisms, independent of tear deficiency and evaporation. In this review we summarize current knowledge on animal models that mimic both the severity and chronicity of inflammatory DED and that have been reliably used to provide insights into the immunopathological mechanisms of DED, and we provide an overview of the opportunities and limitations of the rabbit model in investigating the role of both ocular and nasal mucosal immune systems in the immunopathology of inflammatory DED and in testing novel immunotherapies aimed at delaying or reversing the uncontrolled age-related inflammatory DED.

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