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Age-Related Changes in the Anatomy of Language Regions in Autism Spectrum Disorder

Authors
  • Knaus, Tracey A.1
  • Silver, Andrew M.1
  • Dominick, Kelli C.1
  • Schuring, Melanee D.1
  • Shaffer, Nancy1
  • Lindgren, Kristen A.1
  • Joseph, Robert M.1
  • Tager-Flusberg, Helen1
  • 1 Boston University, Department of Anatomy and Neurobiology, School of Medicine, 715 Albany Street L-814, Boston, MA, 02118, USA , Boston (United States)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Oct 04, 2008
Volume
3
Issue
1
Pages
51–63
Identifiers
DOI: 10.1007/s11682-008-9048-x
Source
Springer Nature
Keywords
License
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Abstract

Impairments in language and communication are core features of autism spectrum disorder (ASD). The anatomy of critical language areas has been studied in ASD with inconsistent findings. We used MRI to measure gray matter volume and asymmetry of Heschl’s gyrus, planum temporale, pars triangularis, and pars opercularis in 40 children and adolescents with ASD and 40 typically developing individuals, each divided into younger (7–11 years) and older (12–19 years) cohorts. The older group had larger left planum temporale volume and stronger leftward asymmetry than the younger group, regardless of diagnosis. The pars triangularis and opercularis together were larger in ASD than controls. Correlations between frontal language areas with language and symptom severity scores were significant in younger ASD children. Results suggest similar developmental changes in planum temporale anatomy in both groups, but group differences in pars triangularis and opercularis that may be related to language abilities and autism symptom severity.

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