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Ageing and cancer: a research gap to fill.

Authors
  • Solary, Eric1, 2, 3
  • Abou-Zeid, Nancy1
  • Calvo, Fabien1, 4
  • 1 Fondation « Association pour la Recherche sur le Cancer », Villejuif, France. , (France)
  • 2 Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France. , (France)
  • 3 Gustave Roussy Cancer Center, INSERM U1287, Villejuif, France. , (France)
  • 4 Université de Paris, France. , (France)
Type
Published Article
Journal
Molecular Oncology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2022
Volume
16
Issue
18
Pages
3220–3237
Identifiers
DOI: 10.1002/1878-0261.13222
PMID: 35503718
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The complex mechanisms of ageing biology are increasingly understood. Interventions to reduce or delay ageing-associated diseases are emerging. Cancer is one of the diseases promoted by tissue ageing. A clockwise mutational signature is identified in many tumours. Ageing might be a modifiable cancer risk factor. To reduce the incidence of ageing-related cancer and to detect the disease at earlier stages, we need to understand better the links between ageing and tumours. When a cancer is established, geriatric assessment and measures of biological age might help to generate evidence-based therapeutic recommendations. In this approach, patients and caregivers would include the respective weight to give to the quality of life and survival in the therapeutic choices. The increasing burden of cancer in older patients requires new generations of researchers and geriatric oncologists to be trained, to properly address disease complexity in a multidisciplinary manner, and to reduce health inequities in this population of patients. In this review, we propose a series of research challenges to tackle in the next few years to better prevent, detect and treat cancer in older patients while preserving their quality of life. © 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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