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Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis.

Authors
Type
Published Article
Journal
AJNR. American journal of neuroradiology
Publication Date
Volume
23
Issue
8
Pages
1327–1333
Identifiers
PMID: 12223373
Source
Medline
License
Unknown

Abstract

GM volume loss appears to be a constant, linear function of age throughout adult life, whereas WM volume loss seems to be delayed until middle adult life. Both appear to be independent of sex. Quantitative analysis of %GM and %WM volumes can improve our understanding of brain atrophy due to normal aging; this knowledge may be valuable in distinguishing atrophy of disease patterns from characteristics of the normal aging process.

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