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Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.

Authors
Type
Published Article
Journal
Journal of Virology
0022-538X
Publisher
American Society for Microbiology
Publication Date
Volume
88
Issue
19
Pages
11070–11079
Identifiers
DOI: 10.1128/JVI.01866-14
PMID: 25008929
Source
Medline

Abstract

La Crosse virus (LACV) is the primary cause of pediatric viral encephalitis in the United States. Although the virus infects both adults and children, over 80% of the reported neurological disease cases are in children. To understand why LACV causes neurological disease primarily in young animals, we used a mouse model where weanling mice, but not adult mice, develop neurological disease following virus infection. We found that an early immune response cell type, myeloid dendritic cells, was critical for protection in adult animals and that these cells were reduced in young animals. Activation of these cells during virus infection or after treatment with type I interferon in young animals provided protection from LACV. Thus, this study demonstrates a reason for susceptibility to LACV infection in young animals and shows that early therapeutic treatment in young animals can prevent neurological disease.

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