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Age changes of human serum polyreactive immunoglobulins (PRIG) activity.

Authors
  • Bobrovnik, S A
  • Demchenko, M A
  • Komisarenko, S V
Type
Published Article
Journal
Ukrainian biochemical journal
Publication Date
Jan 01, 2014
Volume
86
Issue
5
Pages
151–155
Identifiers
PMID: 25816599
Source
Medline
License
Unknown

Abstract

It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy. Therewith, the activity of serum IgG PRIG increases most of all (about 3-4 times), while IgM PRIG activity, on the contrary, does not increase, but sometimes even decreases with age. IgA PRIG activity varies significantly more than IgG PRIG activity and, besides, IgA PRIG significantly less depends on age than IgG PRIG. The age changes in the activity of human serum PRIG, belonging to different types of immunoglobulins, may evidence for the important functional role of these immunoglobulins that has to be clarified.

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