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Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA.

Authors
  • Tsurudome, Y
  • Hirano, T
  • Hirata, K
  • Higure, A
  • Nagata, N
  • Takahashi, K
  • Itoh, H
  • Kasai, H
Type
Published Article
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Publication Date
Nov 01, 2001
Volume
56
Issue
11
Identifiers
PMID: 11682569
Source
Medline
License
Unknown

Abstract

To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.

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