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Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing.

Authors
Type
Published Article
Journal
Analytical and Bioanalytical Chemistry
1618-2650
Publisher
Springer-Verlag
Publication Date
Volume
404
Issue
4
Pages
1181–1196
Identifiers
DOI: 10.1007/s00216-012-6149-6
PMID: 22722742
Source
Medline

Abstract

The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to "frontline" physicians and nurses, and to obtain more precise information more quickly about the health status of a patient. This article gives an overview of recent advances in the field of biosensors, focusing on biosensors based on enzymes, aptamers, antibodies, and phages. In addition, this article attempts to describe efforts to apply these biosensors to clinical testing and cell analysis.

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