Sialography by a hydrostatic technique was performed on 102 patients with Sjøgren's syndrome, 123 patients with rheumatoid arthritis, 17 patients with various connective tissue diseases, 81 patients with miscellaneous forms of arthritis and 74 control subjects. Inter- and intra-observer error in the interpretation of sialographic abnormalities was low and could be completely excluded by using a simple template when reading the sialograms. Sixty of the 102 patients with Sjøgren's syndrome had sialographic abnormalities; 18 had punctate, 14 globular and 15 cavitary sialectasis. Atrophy of the parotid gland was present in 16 patients and dilatation of the main parotid duct in 22 patients. Minor sialographic abnormalities were noted in the other clinical groups. Hydrostatic sialography was been a safe and efficient method of examining salivary glands of patients with Sjøgren's syndrome and avoids the danger of gland rupture that may complicate hand injection methods.