Abstract We retrieved and analysed the records of 527 odontogenic tumours from a total of 62,565 cases in the department of tumour pathology in the Institute of Oncology, University of Istanbul, from 1971 to 2003. Of these 527 tumours, 521 were benign and 6 were malignant. The most common lesions were ameloblastomas ( n = 133) followed by odontomas ( n = 109), odontogenic myxomas ( n = 83) and others. There were more female patients ( n = 278, 53%) than male, and nearly half the patients ( n = 253, 48%) were between the ages of 10 and 29 years. The posterior mandible was the commonest site ( n = 184, 35%), followed by the premolar area of the mandible ( n = 98, 19%), and the anterior maxilla ( n = 84, 16%).