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Some relationships between adrenal function and the effectiveness of a period of isolation in inducing intermale aggression in albino mice

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
6
Issue
1
Identifiers
DOI: 10.1016/0031-9384(71)90008-4
Keywords
  • Acth
  • Adrenalectomy
  • Aggression
  • Corticosterone
  • Dexamethasone
  • Stress

Abstract

Abstract Because an inverse relationship has been demonstrated by numerous authors between aggressiveness and adrenal function in rodents, a series of experiments, in which manipulations of the pituitary/adrenal axis were carried out, was undertaken to determine whether this had any modulating influence on fighting behavior. The effects of adrenalectomy, dexamethasone blocking of the pituitary and of ACTH injection on isolation-induced aggression in the immature, naive and the mature, sexually experienced male albino laboratory mouse are described. It was found that whilst adrenalectomy reduced aggression, dexamethasone blocking enhanced it and ACTH injection reduced it, although the differences were not always significant. The possible mode of action of ACTH in reducing aggression and the consequences to natural populations of rodents is discussed.

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