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Citrullinated proteins in Rheumatoid Arthritis

Authors
Publisher
Elsevier España
Volume
7
Issue
1
Identifiers
DOI: 10.1016/s2173-5743(11)70011-9
Keywords
  • Citrullination
  • Rheumatoid Arthritis
  • Anti-Citrullinated Protein Antibodies
  • Citrulinación
  • Artritis Reumatoide
  • Anticuerpos Antiproteínas Citrulinadas
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.

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