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Monosodiuml-glutamate-induced convulsions—II. Changes in catecholamine concentrations in various brain areas of adult rats

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
16
Issue
5
Identifiers
DOI: 10.1016/0306-3623(85)90009-6
Disciplines
  • Biology

Abstract

Abstract 1. 1.|Norepinephrine (NE) and dopamine (DA) levels in various brain regions were measured in a model of experimentally produced convulsions by monosodium l-glutamate (MSG) administration to adult rats. 2. 2.|Stress by injection of all solutions produced a 60% decrease in NE level in forebrain, recovering its basal value at 15 min after injection. 3. 3.|A significant reduction of brain NE and DA levels of MSG-injected animals was found in the preconvulsive stage, particularly in the forebrain. 4. 4.|No significant variations in catecholamine levels were seen in brain stem and cerebellum as a result of MSG injection. 5. 5.|It is suggested that the changes found in endogenous catecholamine concentration in the forebrain may play a physiological role in the mechanisms of production of convulsions in the MSG model.

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