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An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
19
Issue
17
Identifiers
DOI: 10.1016/j.tetasy.2008.08.009

Abstract

Abstract An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase-catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities ( E >100) were observed when the lipase PS-catalysed reactions were performed with H 2O (0.5 equiv) in diisopropyl ether at 45 °C. The products could be easily separated and were obtained in good yields of ⩾40%.

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